Genome-wide mapping and analysis of aryl hydrocarbon receptor (AHR)- and aryl hydrocarbon receptor repressor (AHRR)-binding sites in human breast cancer cells
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چکیده
منابع مشابه
Wistar Han Aryl Hydrocarbon Receptor (AhR)
Unknown, but the effects seem limited. Rats homozygous for the mutant allele have a dramatically increased LD50 for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and PCDD (penta-), but not HCDD (hexa-). Overall, the tissue distribution and excretion of TCDD in rats homozygous for the AhR mutation is similar to that of the Long-Evans rat, which was used as a dioxin-sensitive control strain. Reprodu...
متن کاملTransgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity
BACKGROUND The aryl hydrocarbon receptor repressor (AhRR) is known to repress aryl hydrocarbon receptor (AhR) signaling, but very little is known regarding the role of the AhRR in vivo. OBJECTIVE This study tested the role of AhRR in vivo in AhRR overexpressing mice on molecular and toxic end points mediated through a prototypical AhR ligand. METHODS We generated AhRR-transgenic mice (AhRR ...
متن کاملRepression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator.
Activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin causes altered gene expression and toxicity. The AHR repressor (AHRR) inhibits AHR signaling through a proposed mechanism involving competition with AHR for dimerization with AHR nuclear translocator (ARNT) and binding to AHR-responsive enhancer elements (AHREs). We sought to delineate the relative roles of...
متن کاملInteractions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways.
Most if not all of the toxic responses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are mediated through the AhR, which requires ARNT to regulate gene expression. ARNT is also required by HIF-1alpha to enhance the expression of various genes in response to hypoxia. Since both the AhR and hypoxia transcriptional pathways require ARNT, some of the effects of TCDD and similar types of ligands cou...
متن کاملAryl hydrocarbon receptor and lung cancer.
The leading cause of lung cancer is exposure to cigarette smoke and other environmental pollutants, which include formaldehyde, acrolein, benzene, dioxin, and polycyclic aromatic hydrocarbons (PAHs). PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important ste...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2017
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-017-2022-x